ACKR4 - Atypical chemokine receptor 4

Order number: 71611

€12,800.00*

Prices plus VAT plus shipping costs

Ready to ship today

Amount (µg)

Biotinylated copolymer

Enables the immobilization of your target for interaction studies (via SPR or GCI).

€500.00*

Matching empty disc

Copolymer-stabilized lipids (HEK293 or T. ni) as control (same as target preparation).

€200.00*

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Atypical chemokine receptor 4 (ACKR4). Unlike classical chemokine receptors, it is structurally unable to trigger canonical heterotrimeric G-protein-mediated signaling or directly induce cell migration. Instead, its primary biological function is to act as a scavenger/decoy receptor. Because ACKR4 controls the gatekeeping network of immune cell migration, it has emerged as a high-interest target across oncology, immunology, and cardiovascular medicine.

Our ACKR4 protein has been solubilized and stabilized using Cube Biotech's NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for a wide range of research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature
Alternative names	C-C chemokine receptor type 11, CCRL1, CCBP2
UniProt ID	Q9NPB9
Protein class	GPCR
Subclass	Class A (Rhodopsin)
Organism	Homo sapiens
Expression host	Insect (Trichoplusia ni)
Sequence, One-Letter Code	MKTIIALSYIFCLVFADYKDDDDKALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNSMVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAVHGWVLGKIMCKITSALYTLNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFCVWMAAILLSIPQLVFYTVNDNARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTLMKMPNIKISRPLKVLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVTESIALFHSCLNPILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEFPFDSEGPTEPTSTFSI
Residues	1-350/td>
Affinity tags	HA signal peptide, FLAG-tag (N-terminal); Rho1D4 (C-terminal)
Size (excluding additional elements)	362 amino acids, 41 kDa
Concentration	0.4 - 0.7 mg/mL
Purity	>90%, determined via SDS-PAGE
Purification process	2-step purification
Shipping	Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function	Atypical Chemokine Receptor 4 (ACKR4) acts as a scavenger that internalizes and degrades homeostatic chemokines (CCL19, CCL21, CCL25, and CCL20), thereby generating the precise directional gradients necessary for proper immune cell trafficking into lymph nodes. Because it controls the spatial positioning of T cells and dendritic cells, modulating ACKR4 is a high-priority strategy to either rescue defective anti-tumor immunity in checkpoint-resistant cancers or mitigate unchecked leukocyte recruitment in inflammatory diseases.
PubMed ID	37449198, 32289156, 38597217, 39623381

ACKR4 - Atypical chemokine receptor 4

Description

Datasheets

Citations