HTR7 - 5-hydroxytryptamine receptor 7

Order number: 71071

€12,800.00*

Prices plus VAT plus shipping costs

Ready to ship today

Amount (µg)

Biotinylated copolymer

Enables the immobilization of your target for interaction studies (via SPR or GCI).

€500.00*

Matching empty disc

Copolymer-stabilized lipids (HEK293 or T. ni) as control (same as target preparation).

€200.00*

Description

We are excited to introduce our off-the-shelf, full-length, active, and native 5-hydroxytryptamine receptor 7 (HTR7). HTR7 is part of the serotonin receptor family and mainly expressed in the central nervous system. It plays a crucial role in neuroplasticity and is the master regulator of the circadian rythm.

Our HTR7 protein has been solubilized and stabilized using Cube Biotech's NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for a wide range of research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature
Alternative names	HTR7, Serotonin receptor 7, 5-HT7
UniProt ID	P34969
Protein class	GPCR
Subclass	Class A (Rhodopsin)
Organism	Homo sapiens
Expression host	Insect (Trichoplusia ni)
Sequence, One-Letter Code	MKTIIALSYIFCLVFADYKDDDDKMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHDGSSGTETSQVAPA
Residues	1-479/td>
Affinity tags	HA signal peptide, FLAG-tag (N-terminal); Rho1D4 (C-terminal)
Size (excluding additional elements)	499 amino acids, 55 kDa
Concentration	0.4 - 0.7 mg/mL
Purity	>90%, determined via SDS-PAGE
Purification process	2-step purification
Shipping	Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function	The HTR7 gene encodes the 5-HT7 receptor, a G-protein-coupled receptor that regulates cyclic AMP signaling to modulate neuroplasticity, circadian rhythms, cognition, and smooth muscle relaxation. Consequently, blocking this receptor is a proven strategy for treating major depression and schizophrenia, while activating it shows therapeutic potential for addressing neurodevelopmental and sleep disorders.
PubMed ID	40534501, 39455564, 34164474, 39334486

HTR7 - 5-hydroxytryptamine receptor 7

Description

Datasheets

Citations