OPRL1 - Nociceptin receptor

Order number: 71091

€12,800.00*

Prices plus VAT plus shipping costs

Ready to ship today

Amount (µg)

Biotinylated copolymer

Enables the immobilization of your target for interaction studies (via SPR or GCI).

€500.00*

Matching empty disc

Copolymer-stabilized lipids (HEK293 or T. ni) as control (same as target preparation).

€200.00*

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Nociceptin receptor (OPRL1). OPRL1
is a G-protein coupled opioid receptor that binds to the neuropeptide nociceptin to modulate pain signalling, stress responses, and emotional behaviour. Its clinical relevance is in neuropsychiatry and addiction medicine and can be a key target for treating chronic pain, anxiety disorders, and substance abuse.

Our OPRL1 protein has been solubilized and stabilized using Cube Biotech's NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for a wide range of research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature
Alternative names	OOR, ORL1, Kappa-type 3 opioid receptor (KOR-3), Orphanin FQ receptor
UniProt ID	P41146
Protein class	GPCR
Subclass	Class A (Peptide)
Original host	Homo sapiens
Expression system	Insect (Trichoplusia ni)
Sequence, One-Letter Code	MKTIIALSYIFCLVFADYKDDDDKEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPAGSSGTETSQVAPA
Affinity tags	HA signal peptide, DYKDDDDK-tag (N-terminal); Rho1D4-tag (C-terminal)
Size (excluding additional elements)	390 amino acids, 43 kDa
Concentration	0.4 - 0.7 mg/ml
Purity	>90%, determined via SDS-PAGE
Purification process	2-step purification
Shipping	Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function	G-protein coupled receptor that binds the endogenous peptide nociceptin/orphanin FQ to modulate complex processes like pain signaling, anxiety, and reward. Therapeutically, it is a significant target for developing "non-mu" analgesics and treatments for substance use disorders, as its activation can oppose the addictive effects of traditional opioids while providing pain relief with a lower risk of respiratory depression.
PubMed ID	35983908, 29197086, 40951290, 30152845

OPRL1 - Nociceptin receptor

Description

Datasheets

Citations

Lab Results