Maleimide Activated

Our Epoxy Activated Agarose resind and MagBeads are carrying an epoxy functionality. With this activated epoxy group Proteins can be bound to the beads covalently via free amines, thiol groups or hydroxyl groups. Therefore the subsequent use of our Epoxy Beads is dependend on your coupled biomolecule.

Fig. 1: Structural formula of a maleimide group

Overview of Cube Biotech's Maleimide Activated Beads for biomolecule coupling via carboxy groups.


Maleimide agarose resin (40 µm)	Maleimide Activated MagBeads (30 µm)
Maleimide Activated Agarose Resin (XL sized)	Maleimide Activated MagBeads (XL sized)

Features

Usage	Coupling proteins to via their activated thiol groups
Specifity	Affinity to thiol groups
Bead Ligand	Affinity agarose with activated Maleimide groups

Maleimide acivated agarose resins and MagBeads from Cube Biotech were successfully used in the following publications and patents:

Targeted Protein	Activated chemical group	Year	Author	Product
cap-specific nucleoside 2′-O-methyltransferase.	Maleimide	2016	Roos T., Yazdan Oanah B., Conzelmann M., Thess A., Buob D., Kunze M., Wagner V.2016-August-12¹	Maleimide Agarose resin [40µm]
Recombinant mutant PPases	Maleimide	2018	Kunze M., Hadler F.N., Yazdan Panah B.,Ross T. ²	Maleimide Agarose resin [40µm]
P2-GM1os	Maleimide	2019	Mahon C.S., Wildsmith G.C., Haksar D., de Poel E., Beekman J.M., Pieters R.J., Webb M.E., Turnbill W.B.³	Maleimide Agarose resin [40µm]

References

Roos T., Yazdan Oanah B., Conzelmann M., Thess A., Buob D., Kunze M., Wagner V. inventor; Method for adding cap structures to rna using immobilized enzymes. International patent: WO2016193226A1. 2016-December-08
Kunze M., Hadler F.N., Yazdan Panah B.,Ross T. inventor; CureVae AG, Tübingen, Immobilized Inorganic Pyrophosphatase (Ppase), Us-Patent: US 2019 / 0177714 A1; September-21-2018
Mahon S. et al. (2019). A ‘catch-and-release’ receptor for the cholera toxin. Faraday Discussions. 10.1039/C9FD00017H.

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